Chlamydia pneumoniae-induced atherosclerosis in a rabbit model.
نویسنده
چکیده
In order to establish a causative relationship between Chlamydia pneumoniae and atherosclerosis, animal models have been proposed. In a rabbit model, arterial intimal thickening has been induced by direct intravascular and intranasal inoculation with C. pneumoniae. C. pneumoniae infection can induce significant acceleration of atherosclerosis in a mildly hyperlipidemic rabbit model but is prevented by treatment with azithromycin. Together these preliminary rabbit experiments suggest that C. pneumoniae may play a causative role in atherosclerosis. More animal studies are underway that are designed to address further mechanistic and therapeutic questions regarding the association between C. pneumoniae and atherosclerosis.
منابع مشابه
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OBJECTIVE To review the literature for evidence that chronic infection with Chlamydia pneumoniae is associated with atherosclerosis and acute coronary syndromes. DATA SOURCES MEDLINE and Institute of Science and Information bibliographic databases were searched at the end of September 1998. Indexing terms used were chlamydi*, heart, coronary, and atherosclerosis. Serological and pathological ...
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عنوان ژورنال:
- Clinical and diagnostic laboratory immunology
دوره 6 6 شماره
صفحات -
تاریخ انتشار 1999